|
|
|
Sunday, June 15
|
11:00 AM |
Registration
|
Alumni Hall |
2:00 - 2:15 PM |
Opening Remarks
Symposium Chair:
 Barry Gold, University of Pittsburgh
Program Chairs:
Mark Murcko, Vertex Pharmaceuticals
Peter Wipf, University of Pittsburgh
|
Alumni Hall |
2:10 - 5:30 PM
2:15 PM
3:05 PM
3:55 PM
4:05 PM
4:55 PM
|
Oral Session 1
Hepatitis C
Session Chair: Robert Schooley, University of California, San Diego
Challenges of HCV Clinical Development
Robert Schooley, University of California, San Diego
Protease Inhibitors
Milind Deshpande. Achillion
Refreshment Break
Nucleoside Inhibitors
Steven Carroll, Merck Research Laboratories
Non-nucleoside Inhibitors
Rolf Wagner, Abbott
|
Alumni Hall |
6:00 - 7:30 PM |
Welcome Reception |
Cathedral of Learning
|
7:45 – 9:45 PM
7:50 PM
8:20 PM
8:50 PM
9:20 PM |
Oral Session 2
Virtual Library Design and Screening
Session Chair: Patrick Walters, Vertex Pharmaceuticals
Numerical Characterization of Structure-Activity Relationships from a Medicinal Chemist's Point of View
Rajarshi Guha, Indiana University
QSAR: Where Statistics and Chemistry Collide
Robert Sheridan, Merck
Rule of 5, Rules of Thumb and Physicochemical Properties: How Do We Apply Them and Are There Rules At All?
Franco Lombardo, Novartis
Virtual Screening Enrichment Studies: The Devil is in the Details
Andrew C. Good, Bristol-Myers Squibb
|
Alumni Hall |
|
Monday, June 16
|
8:30 AM
|
Welcome Remarks by Arthur S. Levine, M.D.
Senior Vice Chancellor for Health Sciences and Dean,
School of Medicine, University of Pittsburgh
|
|
8:35 AM - 12:30 PM
8:40 AM
9:30 AM
10:20 AM
10:40 AM
11:30 AM
|
Oral Session 3
Molecular Approaches to Cancer Therapy
Session Chair: Robert Abraham, Wyeth Research
Cancer Therapeutic Modalities with Kinase Irreversible Inhibitors
Tarek S. Mansour, Wyeth
Apoptosis Based Anti-Cancer Therapies: A Fragment-Based Approach to Lead Design and Optimization
Maurizio Pellecchia, Burnham Institute
Refreshment Break
Drugging the PI3-Kinase Family
Zachary Knight, Rockefeller Institute
A Global Perspective of Small Molecule-Biochemical Network Interactions
Steve Michnick, University of Montreal
|
Alumni Hall |
12:20 - 1:50 PM |
Lunch
|
Alumni Hall |
2:00 PM - 5:30 PM
2:05 PM
2:55 PM
3:45 PM
4:00 PM
4:50 PM |
Oral Session 4
Targeting Transcriptional Control Via Secondary DNA Structures
Session Chair: Laurence Hurley, University of Arizona
Genome-Wide Regulatory Role of G-Quadruplex DNA as Conserved Cis-Regulatory Motifs
Shantanu Chowdhury, Institute of Genomics and Integrative Biology, India
Structural Studies of G-Quadruplexes Formed in Promoters of Oncogenes
Danzhou Yang, University of Arizona
Refreshment Break
The Function and Chemical Biology of Nucleic Acid G-Quadruplexes
Shankar Balasubramanian, University of Cambridge
Small Molecule Targeting of Transcriptional Control and the Origins of Quarfloxacin, the First G-Quadruplex-Interactive Compound to Reach the Clinic
Laurence Hurley, University of Arizona
|
Alumni Hall |
6:00 - 7:45 PM |
Poster Session A
Posters 101 - 147
|
Alumni Hall |
|
Tuesday, June 17
|
8:30 AM - 12:30 PM
8:35 AM
9:25 AM
10:15 AM
10:35 AM
11:25 AM
|
Oral Session 5
Inflammation/Immunology
Session Chair: Robert Zamboni, Merck Frosst Research
The Discovery of CCR2 Antagonist MK-812
Lihu Yang, Merck Research Laboratories
Structure-Based Design Potent and Highly Selective p38 MAP Kinase Inhibitors
Andrew S. Tasker, Amgen Inc.
Refreshment Break
Substitued Pheranthrene Imidazoles as Potent, Selective, and Orally Active mPGES-1 Inhibitors
Bernard Cote, Merck Frosst Research
Selective Inhibitors of Classic and Novel PKC Isotypes as Immunomodulators
Maurice J. van Els, Novartis
|
Alumni Hall |
12:35 - 12:50 PM |
Box Lunch
|
Alumni Hall |
Afternoon Open |
Open Time / Optional Tours
|
|
8:00 – 10:00 PM |
Poster Session B
Posters 201 - 244
|
Alumni Hall |
|
Wednesday, June 18
|
8:00 AM - 12:00 PM
8:05 AM
8:40 AM
9:15 AM
9:50 AM
10:05 AM
10:40 AM
11:15 AM
11:50 AM |
Oral Session 6
Late-Breaking/First Time Disclosures
Session Chair: William Greenlee (Schering-Plough)
Designing Oral gp120 Inhibitors for the Treatment of HIV
Don Middleton, Pfizer
Discovery of a Unique Class of c-Met Inhibitors for the Treatment of Cancer
Jason Katz, Merck
Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amine hydrochloride (CP-945,598), a Novel, Potent and Selective Cannabinoid CB1 Receptor Antagonist
David Griffith, Pfizer
Refreshment Break
Simulating the Release of Endogenous PTH--A New Therapeutic Approach for the Treatment of Established Osteoporosis
Leo Widler, Novartis Institutes of Biomedical
Research
TG100801: A Topically Administered Kinase Inhibitor for the Treatment of Age Related Macular Degeneration
Moorthy S. S. Palanki TargeGen
Preclinical Characterization of a Selective Glucocorticoid Receptor Modulator
Michael Coghlan, Eli Lilly
Synthesis and Activity of 1-(3-amino-2-hydroxy-1-phenylpropyl)indolin-2-ones: Discovery of Selective Norepinephrine Reuptake Inhibitor WAY-315193 (NRI-193)
Casey McComas, Wyeth
|
Alumni Hall |
12:10 - 2:00 PM |
Lunch
|
Alumni Hall |
1:50 PM - 5:30 PM
1:55 PM
2:00 PM
2:30 PM
3:15 PM
3:30 PM
3:35 PM
4:20 PM
4:25 PM
4:55 PM |
Oral Session 7
ACS Medicinal Chemistry Awards
Session Chair: Donald Abraham, Virginia Commonwealth University
2008 IUPAC Richter Award
Introduction to IUPAC Richter Award
High-Resolution Structures of HIV-1 RT/Rilpivirine Complexes: Strategic Flexibility Explains Potency Against Resistance Mutations
Edward Arnold, Rutgers University
IUPAC Richter Award Lecture: Progress in the Development of Non-nucleoside Reverse Transcriptase Inhibitors: From Tibo to Rilpivirine
Award Winner: Jan Heeres
Refreshment Break
2008 OBC Award
Introduction to OBC Award
OBC Award Lecture: DNA-Osmium Complex for DNA Methylation Analysis
Award Winner: Akimitsu Okamoto, RIKEN,
Advanced Science Institute
2008 Division of Medicinal Chemistry Award
Introduction to Division of Medicinal Chemistry Award
Potent Chimeric NRTI-NNRTI Bifunctional Inhibitors of HIV-1 Reverse Transcriptase
Karen Anderson, Yale University
2008 Division of Medicinal Chemistry Award: Search for Selective Androgen Receptor Modulators (SARMs)
Award Winner: Duane D. Miller, University of
Tennessee at Mephis
|
Alumni Hall |
6:30 - 10:00 PM |
ACS Division of Medicinal Chemistry Awards Banquet |
Carnegie Museum |
|
Thursday, June 19
|
8:30 AM - 12:00 PM
8:35 AM
9:20 AM
10:05 AM
10:20 AM
11:05 AM
|
Oral Session 8
Biomarkers/PET
Session Chair: Donna Huryn, University of Pittsburgh
Click Chemistry-Based Development of New PET Imaging Tracers
Hartmuth Kolb, Siemens Biomarkers
PET Imaging in Drug Development
Terence Hamill, Merck
Refreshment Break
The Development and Application of Pittsburgh Compound B to Human Amyloid Imaging
William E.Klunk & Chester A.Mathis, University of Pittsburgh
Designing Xe-129 Biosensors for In Vivo Magnetic Resonance Imaging
Ivan J. Dmochowski, University of Pennsylvania
|
Alumni Hall |
12:00 PM |
Box Lunch
|
Alumni Hall |
Conference Closes
|
 |
